{"id":205,"date":"2024-02-16T15:52:01","date_gmt":"2024-02-16T14:52:01","guid":{"rendered":"https:\/\/buni.onlinecreation.pro\/?p=205"},"modified":"2024-02-16T15:53:29","modified_gmt":"2024-02-16T14:53:29","slug":"post-doc-position-molecular-and-cellular-mechanisms-involved-in-motor-neuron-diseases","status":"publish","type":"post","link":"https:\/\/buni.onlinecreation.pro\/fr\/2024\/02\/16\/post-doc-position-molecular-and-cellular-mechanisms-involved-in-motor-neuron-diseases\/","title":{"rendered":"Post-doc position: Molecular and cellular mechanisms involved in motor neuron diseases"},"content":{"rendered":"\n<p>The team \u00ab&nbsp;Translational research in Neurogenetic diseases&nbsp;\u00bb, at the <a href=\"https:\/\/www.bordeaux-neurocampus.fr\/qui-sommes-nous\/les-6-unites-de-recherche\/incia\/\">INCIA institute<\/a>, is hiring a post-doctoral fellow.<\/p>\n\n\n\n<p>INCIA is an Institute of the Bordeaux Neurocampus, the research departement in neuroscience of the university of Bordeaux, gathering 800 researchers on 6 research units.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Offer Description<\/h3>\n\n\n\n<p>The project goals are to determine the functions and effects of different isoforms of genes, focusing on genes involved in motor neuron diseases with the aim of better understanding the molecular and cellular mechanisms involved in these disorders.<\/p>\n\n\n\n<p>The postdoctoral researcher will have the objectives to:<br>\u2013 Study the functional role and intracellular localization of selected isoforms of genes by modification of their expression (overexpression or silencing) in various cell lines and human neurons derived from pluripotent stem cells.<\/p>\n\n\n\n<p>\u2013 Generate long read RNASeq data from cell lines and neurons derived from IPSC from patients (in a platform or in the lab according to the skills of the postdoc) and correlate the mutation with the isoforms produced and the phenotype observed.<\/p>\n\n\n\n<p><strong>Needs<\/strong><\/p>\n\n\n\n<p>\u2013 Independent management of the research project<br>\u2013 Data formatting and regular communication with the research team<br>\u2013 Scientific communication (writing of scientific publications, oral presentations)<\/p>\n\n\n\n<p><strong>Skills<\/strong><\/p>\n\n\n\n<p>\u2013 At ease in cell culture (and\/or differentiation of IPSC into neurons)<br>\u2013 Basic molecular biology for production of expression vectors<br>\u2013 +\/- Bioinformatics analysis of RNAseq data and\/or long-read sequencing (or willing to learn).<\/p>\n\n\n\n<p><strong>Research Field<br><\/strong>Neurosciences<\/p>\n\n\n\n<p>Human genetics<br>Biological sciences<\/p>\n\n\n\n<p><strong>City, Country<br><\/strong>Bordeaux, France<\/p>\n\n\n\n<p><strong>Type of Contract<br><\/strong>Temporary 24 months<\/p>\n\n\n\n<p><strong>Job Status<br><\/strong>Full-time<\/p>\n\n\n\n<p><strong>Hours Per Week<br><\/strong>35<\/p>\n\n\n\n<p><strong>Offer Starting Date<br><\/strong>March 1st<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Contact<\/h3>\n\n\n\n<p>Giovanni Stevanin<br><a href=\"javascript:;\">giovanni.stevanin@upmc.fr<\/a> (exclusively at this address)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The team \u00ab&nbsp;Translational research in Neurogenetic diseases&nbsp;\u00bb, at the INCIA institute, is hiring a post-doctoral fellow. INCIA is an Institute [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":206,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-205","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-emploi"],"_links":{"self":[{"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/posts\/205","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/comments?post=205"}],"version-history":[{"count":1,"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/posts\/205\/revisions"}],"predecessor-version":[{"id":208,"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/posts\/205\/revisions\/208"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/media\/206"}],"wp:attachment":[{"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/media?parent=205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/categories?post=205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buni.onlinecreation.pro\/fr\/wp-json\/wp\/v2\/tags?post=205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}